A2M Therapy

A2M Therapy

A2M is a molecule that occurs naturally in your bloodstream and when injected into the painful area, begins to promote healing.

A2M is a pro-tease inhibitor (a substance that breaks down bad proteins) and cytokine transporter (a protein that transports good and bad cells in the body). It does this by using an amino acid “bait”-and-trap mechanism to stop a many bad proteins that break down tissues like collagen and cartilage in joints. A2M also stops inflammatory proteins and it thus disrupts inflammation pathways.

Scientific evidence points to A2M as a possible key that may stop osteoarthritis at the cellular and molecular level. A2M is a Broad Spectrum Multi-Purpose Pro-tease Inhibitor (a powerful chemical in destroying proteins that cause joint degeneration) that captures and inactivates major chemicals that lead to joint breakdown and cartilage damage. Once these bad chemicals are trapped by A2M, the body can then quickly eliminate them.

Alpha 2 Macro-globulin (A2M) injections are a cutting-edge new procedure that may help to alleviate symptoms associated with osteoarthritis and other painful orthopedic conditions. A2M is a human protein molecule that occurs naturally in your bloodstream and when injected into the osteoarthritic or painful area, may begin to promote healing.

A2M May be effective for alleviating symptoms associated with many conditions, Including:

  • Degenerative Disc Disease
  • Joint Pain associated with arthritis and joint degeneration
  • Torn Meniscus in knees
  • Sciatica Nerve Pain From Herniated Disc
  • Neuropathic Pain – Peripheral Neuropathy

What is an Alpha 2 Macro-globulin (A2M) Injection?

With approximately 30+ million of the Americans suffering symptoms of osteoarthritis and degenerative conditions, scientists and other researchers have found a new option in the area of regenerative medicine known as Alpha 2 Macro-globulin (A2M) human plasma protein. The main goal of A2M injection is to target the most common health problems that the people face today.

Human Alpha 2 Macro-globulin (A2M) protects your tissues and boosts natural healing by binding to destructive enzymes that cause cartilage decay and osteoarthritis. These destructive enzymes eat away at your cartilaginous tissue, especially if that tissue has been damaged by a traumatic injury or overuse. As the cartilage degenerates, the joint becomes inflamed, leading to chronic pain and stiffness.

A2M protein molecules binds to these destructive protein and enzymes in your joint rendering them harmless and allowing them to be flushed naturally from your body. The A2M protein molecule itself is large and complex. It travels easily through the bloodstream and gets into joints when your circulation is good. As we age, the blood supply to joints and cartilage decreases not allowing A2M to enter the joints. Also our cartilage does not have blood vessels meaning the bad destructive proteins once they get into our joints, usually from some type of trauma, have no way of getting out of the joint and back into circulation. So these destructive protein and enzymes’ remain in the joints continuing to break down our joints causing degeneration pain and inflammation.

A2M, which is injected into the joints, has the ability to inhibit all four classes of destructive proteins and enzymes by a unique ‘trapping’ mechanism which is then flushed out of the joints and eliminated through circulation.

How does A2M Injection Work?

An A2M injection deposits a rich supply of A2M protein directly into the injured area. The injected protein molecules quickly get to work, binding and removing destructive enzymes from your joint tissue.

At your appointment, your blood will be drawn and spun in a centrifuge to separate it into red and yellow plasma. The yellow plasma, concentrated 6X with A2M protein molecules, will be re-injected into your joint.

The procedure is minimally-invasive, and not painful. Most patients tell us they feel an improvement in symptoms and mobility on the very same day. The anti-inflammatory effects may last for several months and joint cartilage destruction stops, depending on your circumstances. Although you may feel some mild short term soreness over the next couple of days, the down time to exercising and resuming your normal daily activity is only 1-2 days at the most. Most people can continue their regular activity that same day.

Here’s What Our Patients Have to Say

“I could not be more pleased with the results of my treatment at Regenerative Medicine of Raynham! Dr. Petrie was knowledgeable, professional, and friendly. The treatments he provided have improved my quality of life in so many ways….I am able to climb stairs, play golf, and return to other sport activities that I enjoy. Cannot thank him enough!!

Gail B.

“I went to regenerative medicine of raynham about 10 months ago to have my regenerative medicine treatment. I had severe arthritis in my right shoulder and moderate in my left. I am happy to say after this procedure I am now pain free in my left shoulder and have gained almost full use of right. I can’t thank the people at regenerative medicine of raynham enough for making my life easier and with a lot less pain.”

David G.

“I had my first tissue transplant injection to my right hip on October 1st, 2019. The procedure was done in the office, it was painless, and within a short period of time I went from limping in constant pain to walking without a limp and being pain free. The results for me have been exceptional.”

David C.